Precision medicine targeting the root causes of aging: genomic instability, telomere attrition, mitochondrial dysfunction, cellular senescence, and chronic inflammation. We focus on cardiovascular aging—the primary driver of mortality—using BaleDoneen arteriology to detect and reverse arterial disease years before symptoms. Move beyond symptom-based care to protect function, cognition, and vitality through every decade.
Longevity science distinguishes lifespan (years lived) from healthspan (years lived without disease or disability). At Lake Washington Internal Medicine, Dr. Mona Shawky targets the nine hallmarks of aging using evidence-based interventions proven to slow biological aging.
We focus on cardiovascular aging—the #1 cause of death and disability—detecting arterial inflammation, endothelial dysfunction, and microvascular disease using BaleDoneen protocols. High-risk patients receive genetically guided therapy targeting insulin resistance, chronic infection (periodontal pathogens, H. pylori), mitochondrial dysfunction, and cellular senescence—preventing disease before it manifests.
Early detection and reversal of atherosclerosis using inflammatory biomarkers (hsCRP, Lp-PLA2, MPO), NMR lipid analysis, and CIMT/CAC imaging—proven to reduce heart attacks and strokes by up to 98%.
Early detection of prediabetes and metabolic syndrome using fasting insulin, HOMA-IR, continuous glucose monitoring (CGM), and adiponectin—with protocols targeting mitochondrial function and nutrient sensing pathways.
Assessment and optimization of thyroid function, sex hormones (testosterone, estrogen, progesterone), cortisol patterns, and mitochondrial biomarkers—supporting energy production, cognitive function, and resilient aging.
Evidence-based protocols for nutrition (caloric restriction mimetics, protein optimization), exercise (VO2 max training), sleep architecture, stress resilience, and supplement optimization—treating lifestyle as clinical intervention.
Our BaleDoneen-informed cardiovascular and longevity assessment combines inflammatory biomarkers, advanced lipid analysis, metabolic panels, arterial imaging, and optional genomic testing to detect active disease and biological aging acceleration.
Microvascular atherosclerosis progresses silently for decades before causing heart attack, stroke, dementia, or kidney failure. We identify arterial inflammation and plaque vulnerability years pre-symptom—enabling intervention when it’s most effective and disease is still reversible.
Inflammatory & Oxidative Stress Biomarkers: hsCRP, Lp-PLA2, MPO, F2-isoprostanes, homocysteine, fibrinogen—detecting arterial inflammation and oxidative damage
Advanced Lipid Analysis: NMR LipoProfile (particle number/size), apoB, lipoprotein(a), remnant cholesterol—far more predictive than standard cholesterol panels
Metabolic & Insulin Resistance Markers: Fasting insulin, HOMA-IR, HbA1c, adiponectin, OGTT—detecting prediabetes years before diagnosis
Arterial Imaging: CIMT with plaque characterization, CAC scoring, optional CCTA—visualizing disease presence, composition, and vulnerability
Hormonal & Mitochondrial Function: Thyroid (TSH, Free T3, Reverse T3), sex hormones, vitamin D, methylation markers (homocysteine, B12, folate)
Optional Genomic Testing:APOE, MTHFR, PCSK9, Factor V Leiden, TCF7L2—personalizing therapy to your genetic blueprint
We stratify risk with precision, intervene early, and measure progress objectively. The aim is simple and ambitious: to change the anticipated future—toward fewer events, better function, and a life lived on your terms.
Integrating genetics (APOE, PCSK9, Factor V Leiden), inflammatory biomarkers, arterial imaging (CIMT, CAC), and metabolic markers to define current disease status and trajectory—not just population-based risk estimates.
Targeting small vessel disease affecting brain (cognitive decline), kidneys (CKD), and heart (microvascular angina)—using biomarkers and imaging that detect dysfunction before organ damage becomes irreversible.
Medical therapy combined with caloric restriction mimetics, mitochondrial support (NAD+ precursors, CoQ10), senolytic interventions, and exercise prescriptions targeting VO2 max—interventions proven to extend healthspan.
Testing creates value only when translated into action. We interpret complex biomarker patterns, arterial imaging findings, and genetic results—then build a structured, prioritized plan with measurable milestones and quarterly progress tracking.
Comprehensive Assessment Includes:
Longevity is adding life to every year. With proactive cardiovascular prevention, metabolic balance, and functional wellness, you can materially alter your health trajectory and protect what matters most.
We use world-class methods—advanced labs, genetic predisposition insights, and modern imaging—to define your present and design a brighter prospective plan of care. You remain in charge; we provide the precision, structure, and long-term partnership.
Detect arterial inflammation, insulin resistance, and hormone decline 10-20 years before symptoms using biomarkers and imaging—enabling intervention when disease is still reversible.
Target interconnected systems: cardiovascular health protects brain function; metabolic optimization supports mitochondria; hormone balance sustains energy and cognition.
Therapy guided by your genetics (APOE, MTHFR, PCSK9), biomarker trends (not single values), and arterial imaging—personalizing treatment to your biology, not population averages.
For patients seeking broader precision screening and performance optimization, we offer complementary services that integrate seamlessly with longevity care for a unified, physician-led approach.
Comprehensive head-to-toe evaluation including VO2 max testing, cognitive assessment, body composition analysis, and tailored protocols for peak performance, stress resilience, and durable well-being.
Galleri® blood test detecting 50+ cancer types pre-symptom, Whole-Body MRI screening for early-stage malignancies, and liquid biopsy panels for patients with elevated genetic risk (BRCA, Lynch syndrome).
Continuous physician access, coordinated subspecialty referrals, quarterly biomarker tracking, and longitudinal oversight—ensuring each intervention is timely, evidence-based, and aligned with your goals.
If you’re serious about preventing cardiovascular disease, optimizing metabolic health, and slowing biological aging—let’s build an evidence-based plan with measurable outcomes: plaque regression, biomarker improvement, and functional capacity preservation.
